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Senior/Principal Scientist, Discovery

FirstLight Bio, Inc

This is a Contract position in Las Vegas, NV posted December 9, 2022.

Senior/Principal Scientist, Discovery FirstLight Bio , with offices in Manhattan and South San Francisco, was founded in 2021 to create the next generation of genomic medicines.

Our approach is based on cutting-edge breakthroughs in genome editing technology made at Stanford University which enable more precise, effective, and safe avenues to edit the genome.

We are building an exceptional team that is diverse, rigorous, innovative, collaborative and committed to delivering cures to patients.

Position Summary We are seeking a talented, dedicated, passionate, and motivated person with experience in genome editing to join our team in South San Francisco as Senior/Principal Scientist, Discovery.

The successful candidate will join a team developing screening CRISPR editing strategies for cell and gene therapy applications.

As part of a rapidly growing and supportive company, there is an abundance of opportunities to drive career growth and develop new scientific, operational, strategic, and management skills.

Key Responsibilities
· Drive the development and execute high-throughput genome editing screens in mammalian cells.

· Design novel screening studies to maximize the performance of the technology across diverse editing contexts.

· Develop and execute proof-of-concept assays for in vitro phenotypic readouts including qPCR, flow cytometry, NGS, and/or ELISA.

· Work with the SSF team to define the scientific operations and work culture based on collaboration, empathy, and integrity of the SSF lab.

· Analyze and interpret data and present to internal and external audience.

· Contribute to the scientific efforts and develop innovative solutions by maintaining a broad understanding of the field.

· Hire junior scientists and mentor them scientifically and in their career growth.

Requirements
· PhD degree and at least 3 years relevant experience or MS degree with at least 7 years relevant experience.

· Experience with mammalian cell culture.

· Experience with gene editing and genetic screens.

· Technical expertise in transfection, flow cytometry, cell sorting, and next generation sequencing.

· Excellent troubleshooting and written and verbal communication skills.

· Ability to multi-task and excel in a fast-paced environment.

Nice to Have
· Experience with lentiviral transduction and pooled library screening.

· Industry experience managing a high-throughput screening workflow.

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